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Professor Stephen Grant Worthley, M.B., B.S., Ph.D., F.R.A.C.P., F.A.C.C., F.C.S.A.N.Z

Also check this link to the University Staff Directory as it may contain a more updated profile of this staff member including expertise and contact details.

Staff
Ms. Angie Hooper - Personal Assistant
Dr Michel Leung - Post-doctoral Fellow
Dr Kean Soon – Post-doctoral Fellow
Dr Georgy Chacko – Post-doctoral Fellow
Dr Rae Davidson – Post Doctoral Fellow

Higher Degree students
Dr. Karen Teo - PhD
Dr. Cynthia Piantadosi - PhD
Dr Payman Molaee – PhD
Dr Ben Dundon – PhD
Dr Peter Psaltis – PhD
Dr Gary Liew – PhD
Mr Kelvin Wong

Current Funded Research
National Heart Foundation of Australia Research Grant
2003-$55,000
Title: The Role of High Density Lipoproteins in Plaque Stabilisation
Investigators: Nicholls S, Worthley SG, Kee P, Rye KA

Royal Adelaide Hospital Clinical Project Grant
2003-$30,000
Title: Multi-modality Coronary Artery Imaging: A comparative study
Investigators: Worthley SG, Teo KSL

Royal Adelaide Hospital DAWES PhD Scholarship
2004-$25,000, 2005-$25,000, 2006-$25,000
Investigators: Teo KSL, Worthley SG

Royal Adelaide Hospital Clinical Project Grant
2004-$30,000
Title: Multi-modality Coronary Artery Imaging: A comparative study
Investigators: Worthley SG

Proof of Commercial Concept Grant
Faculty of Health Sciences and ARI Pty Ltd.
Three-dimensional evaluation of heart structure and function
2007: $30,000.
Sanders P, Worthley SG.
Teo KSL, Worthley SG.
Cardiovascular Lipid Research Grants.
Multimodality Carotid Imaging in Stroke Prediction
2006: $60,000.
Teo KSL, Worthley SG.

Establishment Gift, the Clive and Vera Ramaciotti Foundations.
Vascular and ventricular abnormalities in diabetes mellitus
2006: $30,000.
Worthley MI, Worthley SG

Sir Edward Dunlop Medical Research Foundation.
Pathogenesis of atrial fibrillation: possible role of platelet and endothelial dysfunction
2008: $30,000; 2009: $30,000
Willoughby S, Worthley MI, Mackenzie L, Worthley SG, Sanders P

Mary Overton Award
Short and Long term effects of anti-platelet therapy on endothelial function
2007: $50,000.
Worthley MI, Worthley SG

Most recent publications

Farouque HMO, Worthley SG, Meredith IT, Skyrme-Jones RAP, Zhang MJ. The effect of ATP-sensitive potassium channel inhibition on resting coronary vascular responses in the human. Circ Res 2002;90:231-6.

Helft G, Worthley SG, Fuster V, Zaman AG, Fayad ZA, Osende JI, Fallon JT, Badimon JJ. Serial noninvasive magnetic resonance imaging documents progression and regression of individual plaques. Circulation 2002;105:993-8.

Worthley SG, Farouque HMO, Helft G, Meredith IT. Coronary artery imaging in the new millenium. Heart Lung and Circulation 2002;11:19-25.

Worthley SG, Fayad ZA. Utility of Cardiovascular Magnetic Resonance Imaging. Heart Lung and Circulation 2002;11:63.

Hope SA, Meredith IT, Farouque HMO, Worthley SG, Plunkett JC, Balazs ND. Time course of plasma adhesion molecules in acute coronary syndromes. Coron Artery Dis. 2002 Jun;13(4):215-21.

Corti R, Fuster V, Fayad ZA, Worthley SG, Helft G, Smith D, Weinberger J, Wentzel J, Miseri G, Mercuri M, Badimon JJ. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation. 2002 Dec 3;106(23):2884-7.

Worthley SG, Helft G, Fuster V, Fayad ZA, Shinnar M, Minkoff LA, Schechter C, Fallon JT, Badimon JJ. A novel non-obstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis. Arterioscler Thromb Vasc Biol 2003;23:346-50.

Worthley SG. Immediate percutaneous coronary intervention for acute myocardial infarction: From “if” to “how”. Critical Care and Resuscitation 2003;5:250-2.

Worthley MI, Corti R, Worthley SG. Combined Neutral Endopeptidase and Angiotension Converting Enzyme Inhibitors (Vasopeptidase Inhibitors): A Promising New Treatment Strategy for Hypertension and Heart Failure. Br J Clin Pharmacol 2004;57:27-36.

Farouque HMO, Worthley SG, Meredith IT. The Effect of ATP-Sensitive Potassium Channel Inhibition on Coronary Metabolic Vasodilation in Humans. Arterioscler Thromb Vasc Biol 2004;24:905-10. 

Roberts-Thomson KC, Teo KSL, Stuklis R, Worthley SG. Left atrial myxoma: magnet or echo?. Intern Med J 2004;34:210-1.

Zaman AG, Kearney MT, Schecter C, Worthley SG, Nolan J. Angiotensin converting enzyme inhibitors as adjunctive therapy in patients with persistent atrial fibrillation. Am Heart J 2004;147:823-7.

Teo KSL, Roberts-Thomson K, Worthley SG. Utility of intravascular ultrasound in the diagnosis of ambiguous calcific left main stenoses. J Invas Cardiol 2004;16:385.

Chugh SK, Scott M, Koppel J, Shewchuk L, Goodhart D, Bonan R, Tardiff JC, Worthley SG, DiMario C, Curtis M, Meredith IT, Anderson TJ. Coronary velocity reserve does not correlate with TIMI frame count in patients undergoing non emergency percutaneous coronary intervention. J Am Coll Cardiol 2004;44:778-82.

Corti R, Fuster V, Fayad ZA, Worthley SG, Helft G, Chaplin WF, Muntwieler J, Weinberger J, Smith D, Mizsei G, Mercuri M, Badimon JJ. Effects of aggressive versus conventional lipid-lowering by simvastatin on human atherosclerotic lesions: a prospective,randomized, double-blind trial by high-resolution MRI. J Am Coll Cardiol 2005;46:106-12.

Worthley SG, Soundararajan K, Reis ED, Helft G, Fayad ZA, Siddiqui M, Nusbaum A, Hollier L. Serial magnetic resonance imaging predicts clinical outcome in an experimental model of spinal cord ischemia. Spinal (in press).

Worthley SG, Helft G, Zhang ZY, Tang C, Zaman AG, Rodriguez OJ, Buchsbaum MS, Fuster V, Machac J, Badimon JJ. In vivo Fluorine-18-Fluorodeoxyglucose PET documents macrophage content in a rabbit model of atherosclerosis. J Nucl Cardiol (submitted).

Worthley SG, Helft G, Zhang ZY, Tang C, Zaman AG, Rodriguez OJ, Buchsbaum MS, Fuster V, Machac J, Badimon JJ. Positron Emission Tomography using 18-fluorine-deoxyglucose monitors progression and regression of macrophage content in an experimental rabbit model. J Nucl Cardiol (submitted).

Worthley SG, Farouque HMO, Cameron JD, Meredith IT. Coronary Artery Remodelling is Associated with Serum Inflammatory Marker Levels in Patients with Stable Angina Pectoris. J Invas Cardiol 2006; 18:28-31.

Worthley SG, Farouque HMO, Baldi M, Williamson J, Malaiapan Y, Meredith IT. The RadiTM Pressure Wire High Sensitivity Thermistor and Culprit Lesion Temperature in Patients with Acute Coronary Syndromes. Int J Cardiol 2006;18:528-31.

Cameron JD, Plunkett JC, Worthley SG, Hope SA, Meredith IT. Systemic inflammatory markers in acute coronary syndromes: association with cardiovascular risk factors and effect of early lipid lowering. Coron Art Dis 2005;16:415-22.

Nicholls SJ, Cutri B, Worthley SG, Kee P, Rye KA, Bao S, Barter PJ. Beneficial Effects of Short Term Administration of High Density Lipoproteins on Size and Composition of Experimental Atherosclerosis. Arterioscler Thromb Vasc Biol 2005; 25:2416-21.

Worthley SG, Helft G, Corti R, Worthley MI, Fayad ZA, Zaman AG, Fallon JT, Fuster V, Badimon JJ. Statin Therapy Alone in Combination with an Acyl-CoA:Cholesterol O-Acyltransferase Inhibitor on Experimental Atherosclerosis. Patho Physiol Thromb Haem (in press).

Worthley MI, Meredith IT, Worthley SG. Disruption of In-Stent Neo-Intima causing Acute Myocardial Infarction. J Invas Cardiol 2006;18:246.

Teo KSL, Piantadosi C, Brown MA, Worthley MI, Disney PJ, Hammett CJK, Waddy PJ, Sanders P, Worthley SG. Percutaneous Closure of Atrial Septal Defects Leads to Reduction in Right Ventricular Volumes and Corresponding Normalisation of Left Ventricular Volumes: Ventricular Interdependence and Cardiac MRI. Heart Lung and Circulation 2006;15S:S36.

Wong K, Mazumdar J, Pincombe B, Worthley SG, Sanders P, Abbot D. Theoretical modelling of micro-scale biological phenomena in human coronary arteries. Med Biol Eng Comput. 2006;44:971-82.

Worthley SG, Worthley MI, Meredith IT. Reply to letter to the Editor. J Invasive Cardiol 2007;18:152-4.

Worthley MI, Worthley SG.  Is thrombus aspiration the appropriate “remedy”?  J Am Coll Cardiol 2007;49:15.

Chevalier B, Serruys PW, Silber S, Garcia E, Suryapranata H, auptmann K, Wijns W, Schuler G, Fath-Ordoubadi K, Worthley S, Thuesen L, Meredith I, Bressers M, Hagai h, Paunovic D for the Nobori 1 Clinical Investigators. Randomised comparison of Noboriä, biolimus A9-eluting coronary stent with a Taxusâ, paclitaxel-eluting coronary stent in patients with stenosis in native coronary arteries: the Nobori1 trial. EuroIntervention 2007;2:426-34.

Meredith, IT, Worthley SG, Whitborn R, Wlaters D, Popma J, Cutlip D, Fitzgerald P.  The next-generation Endeavor™ Resolute stent: 4-month clinical and angiographic results from the Resolute first-in-man trial.  EuroIntervention 2007; 3:50-53.

Dimitri H, Molaee P, John B, Lau DH, Stiles MK, Shashidhar, Leong D, Willoughby S, Brooks AG, Mackenzie L, Worthley MI, Worthley SG, Young GD, Kalman JM, Sanders P. Atrial mechanical function: implications for catheter ablation of atrial fibrillation. Asian Cardiovascular Disease (In Press)

Dundon BK, Worthley MI, Worthley SG. Very Late Drug-eluting Stent Thrombosis. Heart, Lung and Circulation (in press)

Duncan RF, Brown MA, Worthley SG.  Recurrent, multiple cardiac myxoma.  Heart Lung and Circulation (in press)

Dundon BK, Yeend RAS, Worthley SG.  Percutaneous closure of a post-surgical left ventricular  (submitted)

Duncan RF, Brown MA, Worthley SG.  Increasing identification of isolated left ventricular non-compaction with cardiovascular magnetic resonance:  A mini case series highlighting variable clinical presentation.  Heart Lung and Circulation (in print)

Duncan RF, Teo KSL, Worthley SG. Cardiac Magnetic Resonance documentation of a Double Atrial Septal Defect before and after Percutaneous Closure with an Amplatzer Septal Occluder. Int J Card. (Accepted)

Dundon BK, Leong DP, Puri R, Worthley SG.  Patent Foramen Ovale:  Not always a benign foetal remnant (submitted)

Dundon BK, Psaltis PJ, Teo KSL, Worthley MI, Worthley SG.  Cardiac magnetic resonance and ‘augmented’ right to left intro-cardiac shunting through a patent foramen ovale (submitted)

Psaltis PJ, Dundon BK, Teo KSL, Worthley SG.  Delayed presentation of right heart failure secondary to intro-myocardial dissection and ventricular septal defect:  Utiity of cardiac magnetic resonance imaging (submitted)

Book Chapters
Fayad ZA, Worthley SG, Helft G, Foo T, Fuster V. Magnetic Resonance Imaging of the Vascular System. In Fuster V (ed) Hurst's The Heart. McGraw-Hill Co., New York, 10th edition., 2000, Chapter 18B, pp. 609-27.

Worthley SG, Badimon JJ. Magnetic Resonance Imaging of Vulnerable Plaque. In Khachigian L (ed) High Risk Atherosclerotic Plaques: Mechanisms, Imaging, Models and Therapy. Nova press publishers.

Worthley SG, Nicholls S.  Cardiovascular Imaging for Clincial Practice. Jones and Barlettt Publishers, Inc.  2007