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Associate Professor Julian McNeil, MBBS, PhD, FRACP

Also check this link to the University Staff Directory as it may contain a more updated profile of this staff member including expertise and contact details.

Staff
Mrs Laura Laslett, BSC (Hons) MMedSci, Research officer
Dr Simon Burnet, MBBS, FRACP, Honorary-Visiting Rheumatologist

Higher Degree students
Mrs Christine Redmond - PhD

Current Funded Research
2003 - 2004 Osteoporosis Education Clinic Study $25,476

2003 - 2004 Diabetes Shoulder Study $20,381

2001 Musculoskeletal Problems in Diabetes Mellitus $20,300  

Educational grants
2002 Aventis Pharmacia $2,500

Most recent publications
Laslett L, Whitham JN, Gibb C, Gill T, Pink J, McNeil JD.  Improving diagnosis and treatment of osteoporosis: evaluation of a clinical pathway for low trauma fractures.  Arch Osteoporosis 2007 (in press)

Laslett LL, Burnet SP, Jones JA, Redmond CL, McNeil JD.  Musculoskeletal morbidity: the growing burden of shoulder pain and disability and poor quality of life in diabetic outpatients.  Clin Exp Rheum 2007 (in press)

Laslett LL, McNeil JD, Lynch, J.  Patient education: the forgotten link in managing osteoporosis.  Aust Fam Physician 2004;33:121-4.

Smith LL, Burnet S, McNeil JD. Musculoskeletal manifestations of diabetes mellitus.  Br J Sports Med 2003; 37: 30 – 35

Burnet S, McNeil JD.  Musculoskeletal disorders in diabetes mellitus.  Modern medicine 2002; 10: 22 – 27 (Turkish Edition)

Burnet S, McNeil JD.  Musculoskeletal disorders in diabetes mellitus.  Modern medicine 2002; 19: 61 – 68. (Middle East Edition)

Burnet S, McNeil JD. Musculoskeletal disorders in diabetes mellitus.  Medicine Today 2001: December: 43 – 48

Rayner C, Burnet S, McNeil JD. Osseous Sarcoidosis – A magnetic Resonance Imaging Diagnosis. Clin Exp Rheumatol 2002: 20; 546 – 548

Burnet S, McNeil JD. A case of Kaposi’s Sarcoma in an elderly patient with rheumatoid arthritis.  Rheumatology 2002: 41; 107-108

Worthley MI, Farouque HMO, McNeil JD, Wothley SG.  Scleroderma cardiomyopathy presenting with thromboembolism.  Intern Med J 2000;31:27-36.

Human Synovial Cells Express mRNA for NK1, NK3 Tachykinin Receptors Preprotachiykinin and Neutral Endopeptidases.  Di Matteo AC, McNeil JD, Scicchitano R, Reynolds PN, Usher SJ,  Holmes MD - Arthritis Rheum 1997 40 (suppl):1302.

Cleland, Peter Roberts-Thomson.  South Australian Scleroderma Register: Analysis of Deceased Patients.  Pathology (1998) 30, pp. 386-390

Halliday DA, Zettler C, Rush RA, Scicchitano R, McNeil JD.  1998 Elevated Nerve Growth Factor in the Synovial Fluid of Patients with Inflammatory Joint Disease.  Neurochemical Research, Vol. 23, No. 6. 1998: 921-924

Sunic D, McNeil JD, Rayner TE, Andress DL, Belford DA.  1998 Regulation of Insulin-Like Growth Factor-Binding Protein-5 by Insulin-Like Growth Factor I and Interleukin-1a in Ovine Articular Chondrocytes. Endocrinology 139: 2356-2362.

Shabani F, McNeil JD, Tippett L. 1998.  The oxidative Inactivation of Tissue Inhibitor of Metalloproteinases-1  By Hypochlorous Acid is Suppressed by Antirheumatic Drugs.  Free radical research 2-12.

Sunic D, Belford DA, McNeil JD and Wiebkin OW.  1995 Insulin-like growth factor binding proteins (IGF-BPs) in bovine articular and ovine growth plate chondrocyte cultures and their modulation of IGF’s activity.  Biochimica et Biophysica Acta, 1245, 43-48.

Worthley S and McNeil JD.  Leukoencephalopathy in a patient on low dose oral methotrexate therapy for rheumatoid arthritis.  1995 Journal of Rheumatology 22: 335-337.

Halliday DA, McNeil JD, Betts WH and Scicchitano R.  1995 Effects of Tachykinins on articular chondrocyte function.  Methods in the Neurosciences, 24: 170-182

Scicchitano R, Wozniak A, Betts WH and McNeil JD.  1995 Functional assays to determine the effects of mammalian tachykinins on human neutrophils.  Methods in the Neurosciences, 24: 24-40.

McNeil JD.  Seronegative arthritis.  1994 Institute of Medical and Veterinary Science Newsletter 23: 17-19.

Halliday DA, McNeil JD, Betts WH, Scicchitano R 1993  A role for the C-terminal fragment SP(7-11) in the pathogenesis of arthritis.  Regulatory Peptides 46: 195-197

involved in the pathogenesis of inflammatory joint disease.  Medical Hypotheses 40: 227-231

Halliday DA, McNeil JD, Betts WH, Scicchitano R  1993 The substance P fragment, SP(7-11) increases prostaglandin E2, intracellular calcium and collagenase production in bovine articular chondrocytes.  Biochemical Journal 292(1): 57-62

Barbara JAJ, Clarkson AR, LaBrooy J, McNeil JD, Woodroffe AJ  1993 Candida albicans arthritis in a renal allograft recipient with an interaction between cyclosporin and fluconazole.  Nephrology Dialysis and Transplantation.  8: 263-266

Halliday DA, McNeil JD, Scicchitano R 1992  Failure of tachykinins including substance P and its fragments to influence proteoglycan and protein synthesis in bovine chondrocytes in vitro.  Biochemica et Biophysica Acta 1137: 29-33

Young G, Cleland LG, McNeil JD 1991 Cryofibrinogenaemia and digital ulceration.   Australian and New Zealand Journal of Medicine.  21: 444-446

McNeil JD, Horowitz M 1991  Contralateral hemiplegia complicating herpes zoster ophthalmicus. Journal of the Royal Society of Medicine 84: 501-502

McNeil JD, Wiebkin OW, Cleland LG, Skosey JL 1989 Does oxygen radical exposure alter the biological properties of hyaluronic acid?  Free Radical Research Communications 6: 227-233

McNeil JD, Oxygen radicals and tissue damage: the effect of oxygen radicals on the structure and synthesis of hyaluronic acid,  1987, PhD thesis, University of Adelaide

McNeil JD, Wiebkin OW, Cleland LG, Vernon-Roberts B 1986 The generation of reducing ends by exposure of hyaluronic acid to oxygen derived free radicals.  Agents and Actions Supplements 18: 95-101.

Horowitz M, McNeil JD, Maddern GJ, Collins PJ, Shearman DJC 1986 Abnormalities of gastric and oesophageal emptying in polymositis and dermatomyositis.  Gastroenterology 90: 434-439

McNeil JD, Wiebkin OW, Betts WH, Cleland LG 1985 Depolymerisation products of hyaluronic acid after exposure to oxygen derived free radicals.  Annals of the Rheumatic Diseases 44: 780-789

Abstracts and presentations:

Laslett L, McNeil J, Lynch J.  Poor health-related behaviours: Baseline results for a high risk group beginning osteoporosis education.  Int Med J 2005;35:A104.

Laslett L, McNeil J, Lynch J.  Osteoporosis education clinic study: comparing two methods of giving education on osteoporosis.  Australasian Epidemiologist 2004;11(3):48.

Laslett LL, Burnet S, McNeil JD.  Shoulder pain and disability and quality of life do not improve in diabetic patients followed for six months.  Int Med J 2004;34(Suppl.):A100.

Laslett LL, Burnet S, McNeil JD. Measuring the quality of life in a diabetic outpatient population: A pilot study. Int Med J 2003 33(Suppl):A89.

Burnet S, McNeil JD. Rheumatic complaints in an Australian Diabetic Clinic - a pilot survey. Int Med J 2002; 32: (Suppl): A23

Rayner CK, Burnet SP, McNeil JD.  Osseous sarcoidosis--a magnetic resonance imaging diagnosis.  Clin Exp Rheumatol. 2002 Jul-Aug;20(4):546-8.

Burnet SP, McNeil JD.  Kaposi's sarcoma in an elderly patient with rheumatoid arthritis after intra-articular corticosteroids. Rheumatology (Oxford). 2002 Jan;41(1):107-8.

Worthley MI, Farouque HM, McNeil JD, Worthley SG.  Scleroderma cardiomyopathy presenting with thromboembolism.  Intern Med J. 2001 Jan-Feb;31(1):64-5.

Bond C, Pile KD, McNeil JD, Ahern MJ, Smith MD, Cleland LG, Roberts-Thomson PJ.   South Australian Scleroderma Register: analysis of deceased patients.  Pathology. 1998 Nov;30(4):386-90.

Sunic D, McNeil JD, Andress DL, Belford DA.  Insulin-like growth factor binding protein-5 proteolytic activity in ovine articular chondrocyte culture.  Biochim Biophys Acta. 1998 Nov 27;1425(3):567-76.

Sunic D, McNeil JD, Rayner TE, Andress DL, Belford DA.  Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes. Endocrinology. 1998 May;139(5):2356-62.

Halliday DA, Zettler C, Rush RA, Scicchitano R, McNeil JD.  Elevated nerve growth factor levels in the synovial fluid of patients with inflammatory joint disease.  Neurochem Res. 1998 Jun;23(6):919-22.

Addolorata C. DiMateo, Julian D. McNeil, Raffael Scicchitano, Paul N. Reynolds, Sylvia J Usher and Mark D. Holmes.  Human Synovial Cells Express mRNA for NK1, Nks Tachykinin Receptors, Preprotachykinin A and Neutral Endopeptidase.(1997) Arthritis Rheumatology: Supplement 40:S248

F.Shabani, J.D.McNeil, S.Usher, R.Shicchitano and M.Holmes.  Inhibition of IL-8 mRNA synthesis and secretion in rheumatoid synoviocytes as a mechanism of action for glucocorticoids.  (Presentation at the 40th Annual Meeting of the Canadian Federation of Biological Societies,1997).

F.Shabani, J.D.McNeil, S.Usher, R.Shicchitano and M.Holmes.  Inhibition of IL-8 mRNA synthesis and secretion in rheumatoid synoviocytes as a mechanism of action for glucocorticoids.  (Presentation at the Annual Scientific Meeting of the Australian and New Zealand Rheumatology Association, May,1997).

F.Shabani, J.D.McNeil, L.Tippett.  Inactivation of Tissue inhibitor of Metalloproteinases (TIMP-1) by oxidants.  (Australian and New Zealand Journal of Medicine 1996, 26, No. 1:135).

F.Shabani, J.D.McNeil, L.Tippett.  Anti rheumatic drugs inhibit the oxidative inactivation of the Tissue inhibitor of Metalloproteinases (TIMP-1) by hypochlorous acid (HOC1).  (Australian and New Zealand Journal of Medicine 1996, 26, No. 1:134).

F.Shabani, J.D.McNeil, R.Shicchitano and M.Holmes.  Effect of Gold Sodium Thiomalate on in vitro collagenase expression in human synovial fibroblasts.  (Presentation at the Annual Meeting of the Canadian Federation of Biological Societies, 1996)

F.Shabani, J.D. McNeil, R. Shicchitano and M. Holmes.  Transforming Growth Factor-B (TTGF-B) regulates the expression of collagenase and tissue inhibitor of metalloproteinases (TIMP-1) genes in human synovial fibroblasts.  (Presentation at the 39th Annual Meeting of the Canadian Federation of Biological Societies, 1996).

F.Shabani, L. Berkis, L Tippett, C. Easton, J.D. McNeil.  Inactivation of Tissue Inhibitor of Metalloproteinases (TIMP-1) by oxidants and the effects of D-penicillamine.  (Presentation at the 38th Annual Scientific Meeting of the Australian Rheumatology Association (SA branch), September 1994).

Zettler C, Halliday DA, Rush RA, Scicchitano R and McNeil JD. 1996. Elevated nerve growth factor levels in the synovial fluid of patients with rheumatoid arthritis. To be presented at 16th Annual Australian Neuroscience Society Meeting, Adelaide, January 1996.

Sunic D, McNeil JD and Belford DA.1995. The role of insulin-like growth factors (IGFs) and endogenous IGF binding proteins (IGF-BPs) in regulation of proteooglycan synthesis by ovine articular chondrocytes. Presented at annual meeting American College of Rheumatology, San Francisco, October 1995.

Shabani F, McNeil JD, Tippett L and Easton C.1995. Inactivation of tissue inhibitor of metalloproteinases TIMP-1 by oxidants. Presented to 1995 Annual Scientific Meeting of Australian Rheumatology Association, Auckland, New Zealand.

Shabani F, McNeil JD and Tippett L. 1995. Anti-Rheumatic drughs inhibit the oxidative inactivation of TIMP-1 by hypochlorous acid (HOCI). Presented to 1995 Annual Scientific Meeting of Australian Rheumatology Association, Auckland, New Zealand.

Sunic D, McNeil JD and Wiebkin OW. 1994. The in vitro effect of insulin-like growth factors on proteoglycan synthesis by articular and growth - plate chondrocytes. Proceedings of Annual Scientific Meeting of the South Australian Society for Medical Research.

Wiebkin OW, Sunic D, McNeil JD and Belford DA. 1993. Synthesis of proteoglycan and insulin-like growth factor binding proteins by articular and growth plate chondrocytes. Proceedings of Combined Meeting of Australia and New Zealand Orthopaedic Research Society and the Australian Orthopaedic Association.

Sunic D, Belford DA, McNeil JD and Wiebkin OW. 1993. The in vitro effect of insulin-like growth factors on proteoglycan synthesis by articular and grwoth plate chondrocytes: the role of insulin-like growth factor binding proteins. Proceedings 37th Annual Conference Australian Society for Biochemistry and Molecular Biology. p123.

Halliday DA, Shilling S, McNeil JD and Scicchitano R. 1993. Evidence for NK-1 (substance P) receptors on bovine articular chondrocytes. Proceedings 37th Annual Conference Australian Society for Biochemistry and Molecular Biology. p160.

Wiebkin OW, McNeil JD, Sunic D and Chen LM. Insulin like growth factors and cartilage repair.  Differential replacement of de novo keratan sulphate rich proteoglycan into matrix-depleted chondrocyte culture. Aust NZ J Med 1993; 23; (5); 557.

Sunic D, McNeil, JD and Wiebkin O. W. The in vitro effect of insulin-like growth factors on proteoglycan synthesis by articular and growth plate chondrocytes.  Aust NZ J Med 1993; 23; (5); 557.

Halliday, DA, Hill J, McNeil, JD and Scicchitano R. Evidence for substance P receptors on bovine articular chondrocytes. Aust NZ J Med 1993; 23; (5); 552.

McNeil, JD, Easton, C, and Berkis L. Pitfalls in studying the activation of matrix metalloproteinases by oxidants. Aust NZ J Med 1993; 23; (5); 552.

McNeil, JD, Easton, C, and Berkis L. Effects of D-Penicillamine on the activation of matrix metalloproteinases 1 (MMP-1). Aust NZ J Med 1993; 23; (5); 552.

Halliday DA, McNeil JD, Betts WH and Scicchitano R. 1992. The substance P fragment SP7-11 increases intracellular calcium and interacts with a guanine nucleotide - binding protein. Proceedings 17th Annual Conference of the Connective Tissue Society of Australia and New Zealand.

Sunic D, Chen LM, McNeil JD and Wiebkin OW. 1992. The in vitro effect of insulin-like growth factors on chondrocytes (monolayers and explants) from articular and epiphysial cartialge: proteoglycan synthesis. Proceedings 17th Annual Conference of the Connective Tissue Society of Australia and New Zealand.

Halliday DA, McNeil JD and Scicchitano R. 1992. The substance P Fragment SP7-11 increases intracellular calcium and interacts with a guanine nucleotide - binding protein. Third Hanson Sumposium, Adelaide, Australia.
Halliday, DA, McNeil, JD Betts, WH and Scicchitano R. Effects of neuropeptides on articular cartilage chondrocyte function. Aust NZ J Med 1992; 22; (6): 179.

Halliday, DA, McNeil, JD and Scicchitano R. Human recombinant interleukin 1a modulates  the effect of substance P (7-11) on prostaglandin E2 synthesis in bovine articular chondrocytes. Aust NZ J Med 1992; 22; (6): 746.

Halliday, DA, McNeil, JD and Scicchitano R. A C-terminal metabolite of substance P is involved in chondrocyte mediated cartilage destruction. Arthritis and Rheumatism 1992; 35; (9); S174: C47

Halliday, DA, McNeil, JD Betts, WH and Scicchitano R. A role for the C-terminal fragment SP-(7-11) in the pathogenesis of arthritis. Regulatory peptides 1992; 15; (suppl 1): S68.

Halliday, DA, McNeil, JD Betts, WH and Scicchitano R. The effect of substance P (7-11) on prostaglandin E2 production is modulated by human recombinant interleukin 1a. Arthritis and Rheumatism 1992; 35; (9); S218: D29.

Halliday, DA, McNeil, JD and Scicchitano R. A C-terminal metabolite of substance P is involved in chondrocyte mediated cartilage destruction. Arthritis and Rheumatism 1992; 35; (9); S174: C47

Halliday, DA, McNeil, JD Betts, WH and Scicchitano R. Intracellular calcium increases following exposure to substance P (7-11) in isolated bovine articular chondrocytes. Arthritis and Rheumatism 1992; 35; (9); S174: C44.

Kryiacou K., McNeil, J. D., Wiebkin, O. W., and Cleland L. G. Effects of NSAIDs on mature articular and growth plate chondrocytes. To be presented at the European League against Rheumatism Meeting, Budapest, July 1991.

Halliday D., McNeil, J. D., and Scicchitano R. Effects of Substance P on chondrocyte proteoglycan production. Presented at Annual Meeting of the Australian Rheumatology Association, Christchurch, New Zealand Oct 1990.

McNeil, J. D., Liu S., Skosey, J.L. Oxidative inactivation of alpha-1-proteinase inhibitor and alpha-2-macroglobulin and its modification by thiol containing compounds, including anti-rheumatic agents. Aust NZ J Med(1990); 20: 3 (supp1), 503.

McNeil, J. D., Weitz, Z., Liu, S.,  Skosey J.L. Hydrogen peroxide induced alterations of synoviocyte hyaluronic acid production.  Aust NZ J Med(1990); 20: 3 (supp1), 488.

Weitz, Z., McNeil, J. D., Liu, S., Skosey, J. L.  The effect of D-penicillamine on autoactivation of latent neutrophil collagenase. Federation Proceedings (1989).

McNeil, J. D., Weitz, Z., Liu, S., Skosey, J. L.  The effects of oxidants on hyaluronic acid production by synovial cells and a fibrosarcoma cell line.   Proc of1st Pan Pacific Connective Tissue Symposium. (1989).

Xie, D-Q., Weitz, Z., McNeil, J. D., Skosey, J. L.  The inhibitory effects of D-penicillamine, gold compounds and D-∞-tocopherol on lipid peroxidation.  Arthritis Rheum (1989); 32: R28.

Weitz, Z., McNeil, J. D., Liu, S. and Skosey, J. L. Hydrogen peroxide induced inhibition of hyaluronic acid production: possible mechanism. Arthritis Rheum (1989); 32: S145.

McNeil, J. D., Masi, C., Carson, E., Hanna, W., Liu., S. Froelich, C. and Skosey J. L. An in vitro cartilage model for the study of articular destruction in inflammatorey joint disease. Clinical Research (1988); 36: 962A.

McNeil, J. D., Liu, S., and Skosey J. L. Inhibition by gold compounds and D-penicillamine on the ability of oxidants to neutralize the inhibitory effect of alpha-1-proteinase inhibition on neutrophil elastase. Arthritis Rheum (1988); 33: 591.

McNeil, J. D., Hanna, W., Masi, C., Carson, E., Liu, S., Weitz, Z., and Skosey J. L. :A co-culture model to examine cartilage matrix degradation. Arthritis Rheum (1988); 31: 562.

McNeil, J.D., Liu S. and Skosey, J.L.: Effect of gold compounds and D-penicillamine on the ability of oxidants to neutralize the inhibitory effect of alpha-1-proteinase inhibitor on human neutrophil elastase. Clinical Research (1987); 35: 895A.

McNeil, J.D., Chow, D.C. and Skosey, J.L.: Effect of a high molecular weight hyaluronic acid preparation on the stimulation of polymorphonuclear leucocytes. Federation Proceedings (1986); 45: 636.

Wiebkin, O.W., and McNeil, J.D. Both hydrodynamic size and relative extractabilities of cartilage proteoglycans are affected in situ by exogenous reactive species. Proc. XVLth International Congress of Rheumatology. 1985.

Horowitz, M., McNeil, J.D., Maddern, G.J., Collins, P.J. and Shearman., D.J.C.: Abnormalities of gastric and oesophageal emptying in patients with polymyositis and dermatomyositis. Proc. XVLth International Congress of Rheumatology. 1985.

McNeil, J.D., Wiebkin, O.W., Cleland L.G. and Vernon-Roberts B.: Evidence for oxy radical damage to synovial fluid hyaluronic acid in the inflamed joint. Proc. XVLth International Congress of Rheumatology. 1985.

McNeil, J.D., Wiebkin, O.W., Cleland, L.G. and Vernon-Roberts, B.: The effect of oxygen derived free radicals on the synthesis of hyaluronate by synovial cells in culture. Presented at the Symposium on Recent Advances in Connective Tissue Research - Connective Tissue Society of Australia and New Zealand. 26th-29th May 1985.

McNeil, J.D., The generation of reducing ends by exposure of hyaluronic acid to oxygen derived free radicals.  Presented at the "Oxyradicals, oxylipids and inflammation," meeting held in association with the XVIth International Congress of Rheumatology, Sydney, 1985.

McNeil, J.D., Whitehouse, M.W., Quin M. and Cleland L.G.: Use of oleyl alcohol as an inflammagen in the rabbit and the rat.  Aust NZ J Med (1985);15: (suppl. 1)

McNeil, J.D., Cleland, L.G. and Wiebkin, O.W.:  Effects of hyaluronic acid on macrophage Fc receptor binding. Presented to the Connective Tissue Society Meeting, Leura, March 1984.

McNeil, J.D. Oxyradical induced hyaluronate depolymerization.  Address to the Symposium on Oxyradicals at the Annual Scientific Meeting of the Australian Society for Medical Research, Canberra, December 1983.

McNeil, J.D., Wiebkin, O.W. and Cleland, L.G.:  The cytotoxic effect of oxygen derived free radicals on bovine synovial cells in culture. Aust NZ J Med (1984);14 (suppl. 1): 357.

McNeil, J.D., Wiebkin, O.W. and Cleland, L.G.:  Analysis of the molecular weights of hyaluronic acid from inflamed and non-inflamed synovial fluids.  Aust NZ J Med (1984);14 (suppl. 1): 343.

McNeil, J.D., and Cleland, L.G.:  The effect of oxygen derived free radicals on synovial cells in culture. Presented at the meeting of the Connective Tissue Society of Australia and New Zealand, Adelaide, 1983.

McNeil, J.D., Wiebkin, O.W. and Cleland, L.G.:  The depolymerization of hyaluronate. I. Oxygen derived free radicals.  Presented at the meeting of the Connective Tissue Society of Australia and New Zealand, Adelaide, 1983.

McNeil, J.D., Cleland, L.G. and Betts, W.H.:  The cytotoxicity of oxygen derived free radicals. Aust NZ J Med (1983);13: 225.

McNeil, J.D., Wiebkin, O.W., Cleland, L.G. and Betts, W.H.:  Mechanisms of hyaluronic acid degradation by oxygen derived free radicals.  Aust NZ J Med (1983);13: 211.

McNeil, J.D., Wiebkin, O.W., Cleland, L.G. and Betts, W.H.:  Analysis of hyaluronic acid degradation products after exposure to an oxygen derived free radical flux. Connective Tissue Research (1983); 11: 258.

Cleland, L.G., Betts, W.H. and McNeil, J.D.: Possible influence of iron chelators on oxygen radical production at sites of inflammation. Presented as a paper to the Annual Scientific Meeting of the Australian Rheumatism Association, October 1981.