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 Professor
Emeritus Brian Setchell
BVSc (Sydney University)
PhD ScD (University of Cambridge)
Prof. Brian Setchell has a long-standing interest in the physiology, biochemistry,
and endocrinology of the testes and epididymis with particular reference to the
blood-testis barrier, testicular fluids and blood flow, the descent of the testis,
cryptorchidism and the effects of whole body or local heating of the testes on
sperm production, motility, fertilising ability, and the development of embryos
in normal females made pregnant by males whose testes had been heated.
Until the end of 1996, he was Professor of Animal Sciences in the Faculty of
Agricultural and Natural Resource Sciences at the Waite Campus and spent 1997-8
as a Nobel Foundation Fellow and 2000 as a STINT fellow at the Pediatric Endocrinology
Unit, Karolinska Hospital, Stockholm, Sweden. He has published a book "The
Mammalian Testis", and 69 major reviews and chapters in books, 136 original
research articles, and 203 abstracts on the work of his group on the testis
and epididymis, as well as translations of de Graaf's two books on Male and
Female Reproductive Organs (originally published in 1668 and 1672 respectively)
as well as of Sertoli's original 1865 article describing the cells in the testes
named after him. He was given the Distinguished Andrologist award for 1997 by
the American Society of Andrology.
Recent Publications
- JC Bustamante, BP Setchell (2000) The permeability of the microvasculature
of the perfused rat testis to small hydrophilic substances. Journal of Andrology
21: 444-451
- JC Bustamante, BP Setchell (2000) The uptake of amino acids,
in particular leucine, by isolated perfused testes of rats. Journal of Andrology
21: 452-463
- BP Setchell , L Ploen and EM Ritzen (2001) Reaction of long-term
effects of local heating of the testis by treatment of rats with a GnRH agonist
and an anti-androgen. Reproduction 122, 255-263.
- K Jahnukainen ,M Hou ,C Petersen ,BP Setchell and O Soder (2001)
Intratesticular transplantation of testicular cells from leukemic rats causes
transmission of leukemia. Cancer Research 61, 706-710.
- CK Jonsson , BP Setchell , N Martimeller , K Svechnikor and O Soden (2001)
Endotoxin-induced expression in testicular macrophages is accompanied by downregulation
of the constitutive expression in Sertoli cells. Cytokine 14, 283-288
- BP Setchell (2001) Physiologie de la barriere sang-testicule. Andrologie
11, 15-20
- BP Setchell (2002) Innervation and vasculature of the excurrent duct
system. In; The Epididymis. ed B.Robaire and BT hinton, New York , Kluwer
Academic/Plenum Publishers, pp 35-48
- Ghabriel MN, Lu JJ, Hermanis G, Zhu C and Setchell BP (2002) Expression
of a blood-brain barrier-specific antigen in the rat male reproductive tract.
Reproduction , 123, 389-397
- BP Setchell, L Plöen and EM Ritzen (2002) Effect of local heating
of rat testes after suppresion of spermatogenesis by pretreatment with a GnRH
agonist and an antiandrogen. Reproduction, 124.133-140 .
- Setchell BP, Pakarinen P and Huhtaniemi I (2002) How much LH do the
Leydig cell see? Journal of Endocrinology 175, 375-382.
- Gustafsson K, Sultana T, Zetterstrom CK, Setchell BP, Siddiqui A, Weber
G and Soder O (2002) Production and secretion of interleukin-1ý
proteins byrat testis. Biochemical and Biophysical Research Communications.
297, 492-497
- Setchell BP, Hertel T, Soder O. (2003) Postnatal testicular development,
cellular organization and paracrine regulation. In: The Developing Testis
Physiology and Patholophysiology, ed O. Soder. Basel, Karger. pp 24-37.
- Setchell, BP (2004) Hormones: what the testis really sees. Reproduction,
Fertility and Development, (in press)
Other Publications of Interest
- BP Setchell (1978) "The Mammalian Testis" Elek Books,
London Cornell University Press, Ithaca. 450pp
- BP Setchell (1984) " Male Reproduction. Benchmark papers in
Human Physiology Volume 17. Van Nostrand Reinhold Comapny, New York 401pp
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